Rizwan Khan, a Muslim from the Borivali section of Mumbai, suffers from Asperger's syndrome, a form of high-functioning autism that complicates socialization. The adult Rizwan marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who mistake his disability for suspicious behavior. Following his arrest, he meets Radha, a therapist who helps him deal with his situation and his affliction. Rizwan then begins a journey to meet US President Obama to clear his name.

Tobe is about 16, living with her dad and younger brother in LA's San Fernando Valley. She invites a gas station attendant named Harlan to come to the beach with her and her friends. He's from South Dakota, wears a cowboy hat, talks country, and has been a ranch hand. They have a great time, his simple expressions seem like wisdom, he's attentive and polite, and even though he's more than twice her age, she wants to spend time with him. When her father objects, she rebels. Harlan, meanwhile, thinks she's his soul mate, and he starts making plans to get her away from her father. Worlds are set to collide, but which ones?